The role of cadherins in neural plasticity – a project presentation
Field:	Other
Authors:	Stakeberg, Josefina Semb, Henrik Wigström, Holger Mohammed, Abdul
Address of presenting author:	Department of Medical Biochemistry Medicinaregatan 7A Göteborg University, Sweden
E-mail:	josefina.stakeberg@medkem.gu.se
Phone:	031-773 3289
Fax:	031-416108
Text of abstract:	The aim of the project is to study the role of cadherins in synaptic plasticity with focus on learning and memory function of the adult brain. Transgenic mice that express a dominant negative or full-length cadherin in hippocampus, will be created by using the Cre/loxP-system. The advantage of this system is the achievement of a strong cell-specific expression of the genes with no developmental defects. Furthermore, electrophysiological and behavioral analysis of the transgenic mice will be performed in order to establish any differences in activity-dependent synaptic plasticity and in learning and memory skills. The project makes it possible to investigate the role(s) of cadherin mediated adhesion in neural plasticity of the hippocampus at a molecular, cellular and behavioral level.
Keywords:	cadherin, transgenic mice, hippocampus, memory

Created 2000-03-15